If your life is designed in such a way that over time, consistently, you can’t:

• take a number of days off to recover from a flu
• take a number of days off to prevent the spreading of a disease
• take one hour or two to recover from a bad headache or go for a walk
• cancel a business trip
• reschedule a meeting
• go offline for a period of time without fearing something will be wrong when you are back
• ignore an email or a call that comes out of your normal business hours

Then it is perhaps time to consider redesigning your life.